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During the fight sequence, several cult zealots disappear from view. This makes viewing the combat rough. They still fight, but I cannot see their damage bars or estimate their effectiveness. This consistently happens when fighting the Plague Professor.
I use Chrome as a browser, but doubt that would be an issue.
I've encountered the same issue, but its been with more than just the cult zealots, and it seems to occur increasingly often when its a longer battle (pirates, some arenas, heroics).
I too use Chrome as my browser, tomorrow when I play, I'll use IE to test and see if Chrome is indeed the issue or not and put an update here with my findings.