I side more with the idea of presets: http://bbs.tynon.com/showthread.php?...-RUNES-WEAPONS

Setup your heroes once exactly the way you want them, and then the game automatically remembers exactly what you had where for your formation, gear, and rune setup. 3-5 presets would be enough for pretty much anyone here.

Only issue with any of this would be where runes get swapped to during preset changes, but I'm sure it could be handled via a simple "rune inventory" placement switch.