Bane and Adept or a Vengence is essential. In order of importance after those you'd need Vitality, Morale, Hit Rating, Critical, Resilliance, Dodge, Block, and after all those you could use Defensive Runes such as Skill Defense, Phys Defense and Magic Defense depending on what you need. If your just starting, chances are you don't have many rune slots open so you could go with HP, Phys Att, Skill Att, and Morale. It's all about preference and what you happen to need at any given time. In banish event's, where HP isn't really important because Baal or Cerb only needs one swipe to kill you, an HP or Defensive Rune isn't very important, so an offensive rune will be better used. In a PvP battle HP is very important. Keep in mind that other things also very important, such as Gear Level's, Talent Levels and Chip embeds. There are many guides on this forum and many more elsewhere. It's in your best interest to use them
Good luck and enjoy the game






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