Saffron's weakness is she has to land her skill attack. If you don't allow that, either through stun, dodge, or killing her, there isn't all that much she can do to cause difficulty.

That or you can avoid dealing with her for a while with smart use of formation. If she blows her skill attack and then you don't attack her for a few rounds, she loses the shield and can't restore it (especially if she's blocked/dodged in the meantime). With this tactic or the above tactic, you can negate her effectiveness dramatically.

The worst way to deal with Saffron is to let her get that shield up, then attack her head on.

Knowing this, it's also very apparent that Saffron's ideal place in your formation is in the middle row, as there she cannot be avoided no matter your opponent's formation. However, she still has to land her skill attack to be effective, so give her a Preciseness unless you enjoy being frustrated.