Never seen my skill attack on Blood be blocked.
Seen it be dodged plenty of times.
Never noticed any real difference in adding bane and felt the rune slot could be better used for another rune.
He is a dodge master and a time bomb, so my favorites on him are:

1. Adept or vengence
2. Rightiousness lvl 6 or endurance
3. vitality or endurance
4. advantage
5. nimbleness
6. dexteriousness
7. preciseness
8. resistance

extra: any defence rune depending on the situation (only available if you have endurance)

Some have told me that the choice between nimbleness and resistance may cause him to be squishy.
However I like the combo on him.