Oh no, I've gotten several runes from praying that would cost 20 rune fragments. When I get to 10 rune fragments, they never show up again till I use some and have less that ten. My problem is that everytime the Master Rune maker shows up he take 100k coins and leaves me with a Mountain, Trance, or Destruction.
Every rune fragment I got came from the "advanced" rune keeper, when she's not giving me crap ones like the beginner does for 8k