An interesting tip:
Penth does not need Resistance 12 rune to survive.
But, Resistance 12 rune sometimes helps her block the 2nd Adam. If she is able to block the 2nd Adam just one time, they the Adam will not be able to skill the whole battle.
From watching replays, I noticed I was losing some battles because Adam's skill attack would kill my Khan.
After getting Resistance 12 on Penn, I was able to eventually win.