ahmose and saffron are the best tanks in the game. while ahmose got the defense skill on physical and skill damage, his biggest weakness is magic (hr) and saffron is the better overall tank but slightly weaker. also your main makes a great tank too if you believe it or not.
best armor is ofc the best 6 piece armor set you have with the highest power, biggest chips and most HP. the same for the runes, except you want all defense runes (so on top of the ones you mentioned (endurance, reliability, block, dodge) you also want messiness, burliness and flint) and a preciseness rune because you dont want your tank to miss or get dodged when he/she casts the defense skill



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